These skip lesions are to all pathologic examination completely separate from the primary focus of osteogenic sarcoma. Focus of osteogenic sarcoma.
Skip metastases of osteosarcomas are less common than formerly thought found in 1 5 6 5 of patients according to two recent studies 7 8.
Skip lesions osteosarcoma. The natural history of such tumors with skips following ablative surgery is an increased incidence of local recurrence and subsequent pulmonary metastases. Mri detected the skip lesion in both patients and both lesions were confirmed by histology. They are more often found proximal to the primary both intraosseously and transarticularly.
1 assistant professor of orthopaedic surgery alexandria university egypt smouha landmark building 14th may st smouha 21431 alexandria egypt. This paper presents three cases treated by primary amputation and postoperative chemotherapy. Patients and methods the authors retrospectively analyzed the collected.
To spread to the lungs or have skip lesions to other bones and approximately 25 of newly diagnosed patients present with metastatic disease recognizable by modern radio graphy 2. The five patients with only skip metastases at presentation survived an average of 27 2 months range 15 44 months. Purpose the outlook for patients with osteosarcoma who present with synchronous regional bone metastases skip metastases either in the primary bone site or transarticular is considered to be extremely poor.
Secondary bone lesions in the affected limb in osteosarcoma skip lesions its classification and prognosis. Osteosarcoma associated with a skip metastasis sm is a rare occurrence. All patients developed typical pulmonary and subsequent bony metastases.
The impact of modern chemotherapy on this entity has not been previously reported. Histologically these skips represent areas of osteosarcoma which in many cases are a less differentiated form of the tumor. Skip metastases are foci of tumor cells within the same bone as the primary lesion but are separated from the primary focus by normal intervening marrow.
Patients with localized cases are. The cases of osteosarcoma without evident skips were compared to those with verified skips with respect to post operative disease free interval and frequency of local recurrence to determine if there. The authors describe two patients who had high grade osteosarcoma and skip metastasis.
This study was conducted to further investigate the prognostic implication of skip metastases in osteosarcoma. Histologically these skips represent areas of osteosarcoma. Despite advances in the treatment of patients with osteosarcomas those with skip metastases continue to have a poor prognosis and they should be counseled regarding the limitations of current therapies.